Chen C, He M, Zhu Y et al (2015) Five critical elements to ensure the precision medicine. Cancer

Metastasis Rev 34:313318

Chiesi USA, Inc (2020) Announces FDA approval of Bronchitol® (mannitol) inhalation powder

[Internet]. Available from: https://www.chiesi.com/en/chiesi-usa-inc-announces-fda-approval-

of-bronchitol-mannitol-inhalation-powder/

ClinicalTrials.gov (2021) Assessment of clemastine fumarate as a remyelinating agent in multiple

sclerosis [Internet]. Available from: https://clinicaltrials.gov/ct2/show/NCT02040298

Cousin MA, Ebbert JO, Wiinamaki AR et al (2014) Larval zebrash model for FDA-approved drug

repositioning for tobacco dependence treatment. PLoS One 9:e90467

De Boeck K, Haarman E, Hull J et al (2017) Inhaled dry powder mannitol in children with cystic

brosis: a randomised efcacy and safety trial. J Cyst Fibros 16:380387

Delavan B, Roberts R, Huang R et al (2018) Computational drug repositioning for rare diseases in

the era of precision medicine. Drug Discov Today 23:382394

Divorty N, Milligan G, Graham D et al (2018) The orphan receptor GPR35 contributes to

angiotensin II-induced hypertension and cardiac dysfunction in mice. Am J Hypertens 31:

10491058

Drug Repurposing Online (2021) Gold standard drug repurposing online database [Internet].

Available from: https://drugrepurposing.info/

Duloxetine (2021) DrugBank online [Internet]. Available from: https://go.drugbank.com/drugs/

DB00476

Dunoyer M (2011) Accelerating access to treatments for rare diseases. Nat Rev Drug Discov 10:

475476

Everett JR (2015) Academic drug discovery: current status and prospects. Expert Opin Drug Discov

10:937944

FAQs About Rare Diseases (2021) Genetic and rare diseases information center (GARD) an

NCATS program [Internet]. Available from: https://rarediseases.info.nih.gov/diseases/

pages/31/faqs-about-rare-diseases

Finasteride (2021) DrugBank online [Internet]. Available from: https://go.drugbank.com/drugs/

DB01216

Fjerstad M, Trussell J, Sivin I et al (2009) Rates of serious infection after changes in regimens for

medical abortion. N Engl J Med 361:145151

Furosemide (2021) DrugBank online [Internet]. Available from: https://go.drugbank.com/drugs/

DB00695

Genome (2021) Genome-wide association studies (GWAS) [Internet]. Available from: https://

www.genome.gov/genetics-glossary/Genome-Wide-Association-Studies

Ghofrani HA, Osterloh IH, Grimminger F (2006) Sildenal from angina to erectile dysfunction to

pulmonary hypertension and beyond. Nat Rev Drug Discov 5:689702

Gills JJ, LoPiccolo J, Tsurutani J et al (2007) Nelnavir, a lead HIV protease inhibitor, is a broad-

spectrum, anticancer agent that induces endoplasmic reticulum stress, autophagy, and apoptosis

in vitro and in vivo. Clin Cancer Res 13:51835194. Available from: https://pubmed.ncbi.nlm.

nih.gov/17785575/

Godl K, Blencke S, Kurtenbach A et al (2005) Cellular targets of getinib, pp 379383

Govindaraj RG, Naderi M, Singha M et al (2018) Large-scale computational drug repositioning to

nd treatments for rare diseases. npj Syst Biol Appl 4:13

Green AJ, Gelfand JM, Cree BA et al (2017) Clemastine fumarate as a remyelinating therapy for

multiple sclerosis (ReBUILD): a randomised, controlled, double-blind, crossover trial. Lancet

390:24812489

Gupta S, Nihalani N, Masand P (2007) Duloxetine: review of its pharmacology, and therapeutic use

in depression and other psychiatric disorders. Ann Clin Psychiatry 19:125132

Henriksen K, Christiansen C, Karsdal MA (2011) Serological biochemical markers of surrogate

efcacy and safety as a novel approach to drug repositioning. Drug Discov Today 16:967975

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